Experimental Research

PD Dr. med. Jochen Pöling

The activation of the innate immune system is an essential component in the development and progression of cardiovascular diseases. The focus of the experimental research that is carried out at the Schüchtermann-Klinik in close cooperation with the Max Planck Institute in Bad Nauheim is the identification and characterization of the factors and underlying mechanisms that determine the infiltration, activity and residence time of immune cells at the site of damage.

Furthermore, local intercellular interactions between the inflammatory cells and adjacent cell layers are analysed and the pathophysiological relevance of biological adaptation mechanisms clarified. Building on this, intervention strategies are to be derived and created in order to support endogenous cardiovascular healing processes.

The working group has many years of expertise in the application of cardiovascular disease models. For the purposes of further investigation and interpretation, flow cytometric, molecular biological, biochemical, histological and cell culture methods are used in particular.

More information about the working group can also be found on the pages of theMAX-PLANCK-INSTITUTE BAD NAUHEIM.